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Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
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First Report from Colombia of a Urinary Tract Infection Caused by Kluyvera ascorbata Exhibiting an AmpC Resistance

Esteban Artunduaga-Cañas1, Sinthia Vidal-Cañas1, Valentina Pérez-Garay1

  • 1Grupo de Investigación en Salud Integral (GISI), Departamento Facultad de Salud, Universidad Santiago de Cali, Cali 760035, Colombia.

Diseases (Basel, Switzerland)
|July 25, 2025
PubMed

Insights

A rare urinary tract infection (UTI) caused by Kluyvera ascorbata with AmpC resistance was treated successfully. This highlights the need for vigilance in vulnerable patients with complex medical histories.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Diagnostics

Background:

  • Urinary tract infections (UTIs) pose a significant health challenge, especially in immunocompromised individuals with chronic conditions.
  • This case report details a UTI in an elderly male with advanced chronic kidney disease and a history of ESBL-positive infection.

Observation:

  • The patient presented with a UTI caused by Kluyvera ascorbata, a Gram-negative bacillus.
  • Microbiological analysis revealed resistance to ampicillin and cefazolin, but susceptibility to meropenem.

Findings:

  • Intravenous meropenem therapy for 10 days led to clinical recovery.
  • Post-treatment urine cultures were negative, indicating successful eradication of the pathogen.

Implications:

  • This case underscores the importance of identifying and managing UTIs caused by less common pathogens like K. ascorbata, particularly those with AmpC resistance.
  • The findings emphasize the need for robust antimicrobial stewardship and further research into treatment strategies for multidrug-resistant organisms in vulnerable populations.
Keywords:
EnterobacteriaceaeKluyvera ascorbataantibioticbeta-lactam resistancecase reporturinary tract infection

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