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Covalent Organic Frameworks for Immunoassays: A Review
1Henan Province Key Laboratory of New Opto-Electronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.
Biosensors
|July 25, 2025
Summary
Covalent organic frameworks (COFs) enhance immunoassay sensitivity and stability. These novel materials show great potential for electrochemical and optical detection of various targets.
Area of Science:
- Materials Science
- Analytical Chemistry
- Biotechnology
Background:
- Immunoassays are crucial for target detection, but sensitivity and stability improvements are needed.
- Covalent organic frameworks (COFs) offer unique properties like high surface area and stability for sensing applications.
Purpose of the Study:
- To review the advancements of COFs in electrochemical and optical immunoassays.
- To discuss the design and application of COF-based immunoassays for target determination.
Main Methods:
- Summarizing research on COFs as electrode modifiers, signal indicators, and carriers in immunoassays.
- Analyzing typical COF-based immunoassay designs and their performance.
Main Results:
- COFs demonstrate significant potential in improving immunoassay performance.
- COFs serve effectively as electrode modifiers, signal indicators, and enzyme/probe carriers.
Conclusions:
- COFs represent a promising class of materials for developing next-generation immunoassays.
- Further research into COF-based immunoassays will address current challenges and unlock future applications.
Keywords:
covalent organic frameworkselectrochemical immunoassayselectrode materialsoptical immunoassayssignal labelsMore Related Videos
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