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Surgical Management of Desmoid Tumors-Patient Selection, Timing, and Approach
Catherine Sarre Lazcano1, Alessandro Gronchi2
1Division of Surgical Oncology, Department of Surgery, University of Toronto, Toronto, ON M5S 1A1, Canada.
Current Oncology (Toronto, Ont.)
|July 25, 2025
Summary
Desmoid tumors are rare myofibroblastic growths. While active surveillance is often preferred, surgery remains crucial for specific cases to manage symptoms and control local disease.
Area of Science:
- Oncology
- Surgical Oncology
- Pathology
Background:
- Desmoid tumors are rare, deep-seated myofibroblastic neoplasms.
- They exhibit unpredictable behavior, from regression to aggressive local growth, but lack metastatic potential.
- Treatment has evolved from upfront surgery to active surveillance, guided by disease progression and symptoms.
Purpose of the Study:
- To review current treatment strategies for adult desmoid tumors.
- To delineate specific indications for surgical intervention.
- To emphasize patient selection, site-specific considerations, and surgical techniques.
Main Methods:
- Literature review of desmoid tumor management.
- Analysis of surgical roles in current treatment paradigms.
- Discussion of multidisciplinary care principles.
Main Results:
- Active surveillance is a primary approach for many desmoid tumors.
- Surgery remains vital for locoregional control and symptom management in select patients.
- Individualized care considering tumor site, progression, and symptoms is essential.
Conclusions:
- The role of surgery in desmoid tumor management is nuanced and patient-specific.
- Optimizing quality of life and outcomes requires a multidisciplinary approach.
- Careful patient selection and tailored surgical strategies are key for successful treatment.
