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Updated: Sep 13, 2025

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Key Determinants Influencing Treatment Decision-Making for and Adherence to Active Surveillance for Prostate Cancer:
Pani Nasseri1,2, Jorien Veldwijk2, Christa Niehot1
1Department of Urology, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Men deciding on active surveillance for prostate cancer (PCa) weigh risks and benefits. Understanding factors influencing treatment decisions and adherence is crucial for improving uptake and quality of life.
Area of Science:
- Urology
- Oncology
- Decision Science
Background:
- Active surveillance (AS) is an option for low- and intermediate-risk prostate cancer (PCa).
- Men must balance the harms and benefits of AS against active treatment (AT).
- Understanding factors influencing treatment decision-making (TDM) and adherence to AS is essential.
Purpose of the Study:
- To systematically review factors influencing TDM for AS.
- To identify factors affecting adherence to AS protocols.
Main Methods:
- Systematic review following PRISMA guidelines.
- Comprehensive literature search (1990-2024) across Medline, Embase, and other databases.
- Inclusion of studies examining TDM and adherence to AS/active monitoring (AM).
Main Results:
- AS decisions influenced by information, social support, and avoiding side-effects.
- Choosing AT over AS linked to lack of information and fear of progression.
- Adherence to AS associated with quality of life and support; non-adherence due to biopsy burden, uncertainty, or disease upgrading.
Conclusions:
- Numerous factors impact men's treatment pathway choices for PCa.
- Involving family in shared decision-making and providing detailed AS information can improve AS uptake.
- Addressing psychosocial challenges and involving families can enhance AS adherence.
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