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Advanced Bioactive Polymers and Materials for Nerve Repair: Strategies and Mechanistic Insights
Nidhi Puranik1, Shraddha Tiwari1, Meenakshi Kumari2
1Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of Korea.
Journal of Functional Biomaterials
|July 25, 2025
Summary
Bioactive materials promote nerve repair and regeneration by enhancing cell growth and axonal extension. Future advances in manufacturing and personalized medicine will improve their use for treating nerve injuries.
Area of Science:
- Biomaterials science
- Regenerative medicine
- Neuroscience
Background:
- Bioactive materials show promise for nerve repair and regeneration.
- They offer biomimetic structures, enhance cell attachment, and promote axonal extension.
- Current limitations include immune response, fabrication challenges, scalability, and cost.
Purpose of the Study:
- To review the potential of bioactive materials in nerve repair and regeneration.
- To discuss advancements overcoming current limitations.
- To explore future therapeutic applications and the need for a multidisciplinary approach.
Main Methods:
- Review of scaffold-based preclinical studies.
- Discussion of manufacturing advances like 3D bioprinting.
- Exploration of gene editing (CRISPR) and neural interface integration.
Main Results:
- Bioactive materials promote cell growth, tissue repair, and nerve function restoration.
- Preclinical studies demonstrate enhanced nerve repair.
- Advancements are poised to overcome existing limitations.
Conclusions:
- Bioactive materials hold significant potential for treating nerve injuries.
- 3D bioprinting, gene editing, and personalized medicine will enhance effectiveness.
- A multidisciplinary approach is crucial for advancing regenerative medicine for nerve repair.
