Bioactive Peptides Derived from Tuna: Screening, Extraction, Bioactivity, and Mechanism of Action

Area of Science:

• Marine Biotechnology
• Biochemistry
• Food Science

Background:

• Bioactive peptides from natural sources, particularly marine organisms, exhibit significant health benefits.
• Fish-derived peptides are well-researched, but tuna-specific bioactive peptides remain underexplored.
• Tuna processing generates substantial by-products, presenting an opportunity for value-added utilization.

Purpose of the Study:

• To review advancements in the study of tuna-derived active peptides.
• To consolidate information on extraction, purification, screening, and identification strategies.
• To highlight the potential applications of tuna bioactive peptides in pharmaceuticals and functional foods.

Main Methods:

• Literature review of studies on tuna-derived bioactive peptides.
• Analysis of contemporary investigation techniques, including extraction and purification.
• Examination of screening and identification methods such as Yeast Surface Display (YSD) and molecular docking.

Main Results:

• Identification of various bioactive peptides derived from tuna with diverse activities.
• Overview of efficient methodologies for isolating and characterizing these peptides.
• Demonstration of tuna bioactive peptides' potential in antioxidant, antihypertensive, and anti-tumor applications.

Conclusions:

• Tuna bioactive peptides represent a promising, underutilized resource.
• Advanced techniques like YSD and molecular docking facilitate efficient research.
• Further investigation into tuna bioactive peptides can drive innovation in pharmaceuticals and functional foods.