Related Experiment Video
Updated: Sep 13, 2025

Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
Management of Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in Pregnancy
Matthew A Shear1,2, Allie LaTray2, Irene J Chang2
1Division of Maternal-Fetal Medicine and Reproductive Genetics, Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California, 490 Illinois Street, Box 0132, San Francisco, CA 94143, USA.
Abstract:
Multiple acyl-CoA dehydrogenase deficiency (MADD), also known as glutaric acidemia/glutaric aciduria type II (GA II), is an inborn error of fatty acid, amino acid, and choline metabolism. The chronic management of MADD involves both dietary fat and protein restriction to reduce the substrates of the dehydrogenases affected, the avoidance of prolonged fasting as in any fat metabolism disorder, and monitoring for potential complications. Due to its rarity, there is little published experience on the management of MADD in pregnancy. Herein, we report the successful management of a pregnancy in a patient with late-onset or type III MADD, with considerations for preconception, antepartum, intrapartum, and postpartum care.
More Related Videos
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic...
Atherosclerosis III: Management
Chronic Pancreatitis II: Collaborative Care
Assessment:
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Inborn Errors of Metabolism
Lipid Catabolism

