Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A clinically defined and xeno-free hydrogel system for regenerative medicine.

Materials futures·2026

Same author

Author Correction: Physics-informed deep generative learning for quantitative assessment of the retina.

Nature communications·2025

Same author

The Evaluation and Modification of Standard Airway Assessment Tests for Virtual Anaesthetic Assessments: A Pilot Study.

Journal of clinical medicine·2025

Same author

Physics-informed deep generative learning for quantitative assessment of the retina.

Nature communications·2024

Same author

Nutritional care pathways in cancer patients with malignant bowel obstruction: A retrospective multi-centre study.

Clinical nutrition ESPEN·2024

Same author

Endoscopic Gastric Plication in Nonalcoholic Fatty Liver Disease.

The American journal of gastroenterology·2023

Search research articles

Related Experiment Video

Updated: Sep 13, 2025

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

Biopolymers for Liver Tissue Engineering: A Systematic Review.

John Ong^1,2, Jacky Junzhe Zhao³, Carla Swift²

¹Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK.

Gels (Basel, Switzerland)

|July 25, 2025

Summary

Biopolymers are crucial for liver tissue engineering, but current options yield immature cells. Novel biopolymer substrates show promise for improving regenerative therapies for liver disease and clinical translation.

Keywords:

biopolymers cholangiocytes hepatocytes hepatology hydrogels organoids regenerative medicine scaffolds stem cells substrates tissue engineering

More Related Videos

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Published on: May 26, 2016

Related Experiment Videos

Last Updated: Sep 13, 2025

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Three-Dimensional Collagen Matrix Scaffold Implantation as a Liver Regeneration Strategy

Published on: June 29, 2021

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Published on: May 26, 2016

Area of Science:

Regenerative Medicine
Biomaterials Science
Hepatology

Background:

Stem cell-derived liver cells, organoids, and tissues offer regenerative potential for liver disease.
Current culture methods yield immature or unstable liver cell phenotypes compared to native tissues.
Biopolymers in culture substrates and scaffolds critically affect cell and tissue quality and regenerative treatment efficacy.

Purpose of the Study:

To systematically review recent advances in biopolymers for liver tissue engineering.
To provide an overview of current biopolymer applications in the field.
To highlight novel biopolymer substrates with potential for clinical translation.

Main Methods:

Systematic literature review.
Evaluation of biopolymer usage in liver tissue engineering.
Analysis of biopolymer impact on cell and tissue phenotypes.
Assessment of clinical translatability of novel substrates.

Main Results:

Biopolymers significantly influence the quality and maturity of engineered liver cells and tissues.
Existing culture conditions and biopolymer choices present limitations for clinical application.
Emerging biopolymer substrates demonstrate enhanced potential for generating more mature and stable liver constructs.

Conclusions:

Optimizing biopolymer selection and design is essential for advancing liver regenerative medicine.
Novel biopolymer substrates are key to overcoming current limitations in liver tissue engineering.
Further research into clinically translatable biopolymers will accelerate the development of effective liver disease therapies.