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Updated: Aug 17, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Invasive aspergillosis of the sphenoid sinus manifested as a pituitary tumor

H A Fuchs, R M Evans, C R Gregg

    Southern Medical Journal
    |November 1, 1985
    PubMed

    Insights

    Aspergillus sinusitis, a rare fungal infection, is the most common cause of fungal sinusitis. It requires surgical debridement and antifungal treatment when standard antibiotics fail.

    Area of Science:

    • Mycology
    • Otolaryngology
    • Infectious Diseases

    Background:

    • Aspergillus infection of paranasal sinuses is uncommon but represents the most frequent fungal sinusitis.
    • It should be considered in cases of sinusitis unresponsive to antibacterial therapy.

    Observation:

    • A case presented with sphenoid sinus involvement, initially misdiagnosed as a nonfunctioning pituitary tumor.
    • This highlights the diagnostic challenges of fungal sinusitis.

    Findings:

    • Treatment primarily involves surgical intervention for debridement and restoring sinus aeration and drainage.
    • Adjunctive antifungal chemotherapy is a crucial component of management.

    Implications:

    • Early suspicion and diagnosis of Aspergillus sinusitis are vital for effective treatment.
    • Multidisciplinary approaches combining surgery and antifungal agents improve patient outcomes.

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