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Total body PET and Oncology (Invited Commentary)
1King's College London & Guy's and St Thomas' PET Centre and Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, . London, . SE1 7EH, . UK.
Total body positron emission tomography/computed tomography (PET/CT) offers faster, higher-quality scans with reduced radiation. This advancement expands research possibilities, including studies with normal volunteers and dynamic data analysis for improved clinical outcomes.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Radiological Technology
Background:
- Commercially available total body positron emission tomography/computed tomography (PET/CT) scanners have emerged.
- These systems provide full or near-full body coverage in a single scan.
- They offer significant improvements in speed, radiation dose, sensitivity, scan quality, and temporal resolution.
Purpose of the Study:
- To highlight the advancements and implications of total body PET/CT technology.
- To explore new research avenues enabled by enhanced imaging capabilities.
- To discuss the potential impact on clinical applications, particularly in oncology.
Main Methods:
- Utilizing total body PET/CT scanners for comprehensive anatomical and functional imaging.
- Leveraging high sensitivity and temporal resolution for dynamic data acquisition.
- Employing advanced data analysis for kinetic modeling and parametric imaging.
Main Results:
- Enables faster and higher-quality clinical scans with reduced radiation burden.
- Facilitates research in normal volunteer cohorts due to lower radiation exposure.
- Allows for dynamic data acquisition to calculate kinetic indices and generate parametric images, moving beyond static assessments.
Conclusions:
- Total body PET/CT represents a significant technological step forward in medical imaging.
- Advancements in this technology are expected to increase its availability and applications.
- The technology holds promise for improving clinical outcomes in oncology and other fields utilizing PET imaging.
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