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Fiber orientation-dependent T1 angular features in human white matter at 1.5 T, 3 T, and 7 T.

Risto A Kauppinen1, Ekaterina Paasonen2,3, Jeromy Thotland4

  • 1Department of Electric, Electronic and Mechanical Engineering, University of Bristol, Bristol, UK.

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White matter T1 relaxation shows angular features related to axonal fiber orientation across multiple magnetic field strengths. This inherent MRI contrast is detectable in vivo and crucial for quantitative T1 imaging analysis.

Keywords:
T1 relaxationfiber orientationmagnetic field strengthwhite matter

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Area of Science:

  • Neuroimaging
  • Biophysics
  • Magnetic Resonance Imaging

Background:

  • White matter microstructure significantly impacts T1 relaxation times in vivo.
  • Understanding T1 angular features is essential for accurate quantitative MRI analysis.

Purpose of the Study:

  • To quantitatively investigate T1 angular features in human white matter in vivo.
  • To assess these features across different magnetic field strengths (1.5T, 3T, and 7T).

Main Methods:

  • MP2RAGE MRI sequences were used to acquire absolute T1-weighted images.
  • Diffusion MRI (dMRI) was employed to calculate white matter microstructural indices.
  • The fiber-to-field dependency of T1 relaxation was analyzed quantitatively.

Main Results:

  • Two distinct T1 relaxation angular features were observed in white matter (FA > 0.5) at all field strengths.
  • These features include increasing T1 from parallel to perpendicular fiber orientations and a T1 hump around 40°.
  • The magnitude of the 40° hump varied with field strength, suggesting differences in underlying proton species T1.

Conclusions:

  • T1 relaxation anisotropy is an intrinsic contrast in white matter detectable across common human neuroimaging field strengths.
  • This anisotropy must be considered for accurate quantitative T1 MRI evaluations.
  • The findings highlight the importance of accounting for microstructural orientation in T1 relaxometry.