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Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
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Related Experiment Video

Updated: Jul 20, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
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Ki-67 in meningioma: distribution and implications.

Xiaopeng Guo1,2, Ruchit V Patel1, James A Lederer3

  • 11Department of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, Massachusetts.

Journal of Neurosurgery
|July 25, 2025
PubMed
Summary

Ki-67 expression in meningiomas arises from both tumor and immune cells, with varying contributions by grade. Careful interpretation is needed, considering factors like patient age and potential confounders, to accurately assess meningioma prognosis.

Keywords:
Ki-67immune microenvironmentmeningiomamyeloidoncologyprognosis

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Area of Science:

  • Neuro-oncology
  • Immunology
  • Genomics

Background:

  • Ki-67 is a key proliferation marker in meningiomas, crucial for prognosis and treatment decisions.
  • Immune cell infiltration in meningiomas can complicate Ki-67 interpretation due to shared proliferative potential.
  • Understanding the cellular source of Ki-67 is vital for accurate meningioma grading.

Purpose of the Study:

  • To investigate the cellular origin and distribution of Ki-67 within the meningioma microenvironment.
  • To explore the clinical, genomic, and biological associations of Ki-67 expression patterns.
  • To refine the interpretation of Ki-67 as a prognostic marker in meningiomas.

Main Methods:

  • Single-cell mass cytometry (CyTOF) and single-cell RNA sequencing (scRNAseq) profiled 32 meningiomas.
  • Immunohistochemistry assessed Ki-67 index and mitotic count.
  • Molecular Integrated Grade was established using CDKN2A/B deletion and chromosomal alterations; validation in 448 cases.

Main Results:

  • Ki-67 expression was identified in both tumor and immune cells across 77,498 (CyTOF) and 45,460 (scRNAseq) cells.
  • Cellular sources of Ki-67 shifted from myeloid cells in WHO grade 1 to non-immune tumor cells in grades 2 and 3.
  • Elevated Ki-67 was noted in older patients (>70 years) and influenced by radiation; infarction and extramedullary hematopoiesis were identified as non-aggressive confounders.

Conclusions:

  • Ki-67 expression in meningiomas is complex, originating from diverse cell types.
  • Nuanced interpretation of Ki-67 indices is essential, considering potential confounding factors.
  • Ki-67 remains a valuable prognostic marker when evaluated carefully within the tumor microenvironment.