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Related Concept Videos

Gastrulation01:56

Gastrulation

52.8K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs.

Sergio Menchero1, Christopher Barrington2, Clare Critcher1

  • 1Sex Chromosome Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

Developmental Cell
|July 25, 2025
PubMed
Summary
This summary is machine-generated.

Marsupials show accelerated development of anterior structures, uncoupling gene expression and physical growth timelines compared to other mammals. This study reveals novel insights into mammalian developmental diversity and heterochrony.

Keywords:
cross-species comparisonsdevelopmental timingembryogenesisheterochronyopossumorganogenesissingle-cell RNA-seqtranslation

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Area of Science:

  • Developmental biology
  • Comparative genomics
  • Evolutionary developmental biology

Background:

  • Mammalian organogenesis studies predominantly focus on eutherians.
  • Marsupials present unique developmental strategies due to short gestation and external development.
  • Understanding marsupial development offers insights into evolutionary heterochrony.

Purpose of the Study:

  • To create a single-cell transcriptomic atlas of early development in the marsupial Monodelphis domestica.
  • To investigate temporal shifts in organogenesis and anterior feature differentiation.
  • To explore the mechanisms underlying developmental asynchrony in marsupials.

Main Methods:

  • Single-cell RNA sequencing of opossum embryos during gastrulation and organogenesis.
  • Comparative transcriptomic analysis between marsupials and eutherians.
  • Identification of heterochronic gene expression patterns.

Main Results:

  • Identification of novel tissues exhibiting heterochrony in marsupials.
  • Earlier initiation and faster progression of transcriptional programs for anterior structures compared to eutherians.
  • Uncoupling of transcriptional and morphological development timelines.

Conclusions:

  • Marsupials display asynchronous developmental programs, revealing diversity in mammalian developmental sequences.
  • Translation emerges as a potential regulatory mechanism for anterior structure prioritization.
  • This research provides critical insights into the evolutionary plasticity of mammalian development.