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Related Experiment Video

Updated: May 13, 2026

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

Published on: November 11, 2017

Advances in imaging retinal inflammation.

Md Jashim Uddin¹

¹Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee, 37240, USA.

Experimental Eye Research

|July 25, 2025

Summary

Advanced imaging techniques like optical coherence tomography (OCT) and angiography improve the diagnosis and monitoring of retinal inflammation. These technologies offer objective quantification for better patient care in ocular inflammatory conditions.

Keywords:

Inflammation Retina Retinal vascular disease molecular imaging

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Published on: April 21, 2022

Area of Science:

Ophthalmology
Medical Imaging
Inflammatory Diseases

Background:

Retinal inflammation diagnosis and management are critical for ocular health.
Uveal edema, involving iris, ciliary body, and choroid, presents diagnostic challenges.
Traditional clinical grading systems for inflammation lack objectivity and reproducibility.

Purpose of the Study:

To highlight advancements in imaging technologies for quantifying and monitoring retinal inflammation.
To discuss the role of multimodal imaging in comprehensive assessment of ocular inflammatory disorders.
To emphasize the potential of enhanced imaging for therapeutic development and patient care.

Main Methods:

Optical coherence tomography (OCT) for high-resolution retinal architecture visualization.
Widefield fluorescein angiography (FA) for assessing retinal vascular leakage.
OCT angiography (OCTA) for non-invasive microvascular evaluation.
Automated image analysis software for objective quantification of inflammatory markers.

Main Results:

Advanced OCT and FA provide precise quantification of retinal thickness, vitreous haze, and vascular leakage.
OCTA detects microvascular alterations and non-perfusion, aiding in conditions like diabetic retinopathy.
Automated software surpasses traditional grading systems in objectivity for inflammatory markers.
Multimodal imaging offers comprehensive assessment of diverse retinal and choroidal pathologies.

Conclusions:

Novel imaging modalities significantly enhance diagnostic accuracy and monitoring of therapeutic response in retinal inflammation.
These technologies facilitate earlier detection, precise treatment monitoring, and novel therapeutic development for uveitis and other inflammatory eye conditions.
The evolution of imaging promises improved patient care through objective and reproducible assessment of ocular inflammatory diseases.