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Pulmonary Artery Rhabdomyosarcoma: Diagnostic Challenges and Evolving Management
Amanda M Morrison1, Pete P Fong1, Aaron W Aday2
1Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background:
Although typically due to thrombus, pulmonary embolism (PE) can mask rare pathologies, delaying definitive treatment.
Case Summary:
A 38-year-old man with hypertension and chronic venous insufficiency presented with progressive dyspnea and progressive PE despite therapeutic anticoagulation. Imaging raised suspicion for nonthrombotic material in the pulmonary artery. Aspiration thrombectomy revealed gelatinous material confirmed on histopathologic review to be rhabdomyosarcoma of the pulmonary artery. The patient was treated with chemotherapy and radiation. This case emphasizes the need for a high index of suspicion and advanced diagnostics in anticoagulation-resistant PE.
Discussion:
Pulmonary artery sarcomas are rare but crucial to recognize because of their clinical similarity to PE. Advanced imaging and multidisciplinary care are essential for diagnosis and management.
Take-Home Message:
Persistent or atypical PE should prompt consideration of thrombus mimics to expedite appropriate treatment.
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