Related Experiment Video
Updated: Sep 13, 2025

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
Published on: February 15, 2019
Amphiregulin: a potential therapeutic target for tissue fibrosis
1Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
None:
Amphiregulin (AREG), a ligand of the epidermal growth factor receptor (EGFR), plays critical roles in immune homeostasis, cell proliferation, and tissue repair. Recent preclinical studies have shown that AREG is markedly upregulated in various fibrotic diseases and contributes to disease progression through distinct cell sources and signaling mechanisms. These advances highlight AREG as a fibrotic mediator with cellular and organ heterogeneity, suggesting that AREG-targeted therapies can be tailored with great specificity. This review synthesizes recent insights into AREG's expression dynamics, cellular sources, target cell types, and signaling mechanisms in fibrotic diseases, and presents a novel perspective on how this emerging knowledge may inform the development of selective, context-aware antifibrotic therapies.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
TGF - β Signaling Pathway
Mitogens and the Cell Cycle
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:

