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A SEER-based prognostic nomogram for early-stage (pT1-2N0M0) tongue squamous cell carcinoma and an observational analysis of postoperative radiotherapy

  • 0School of Public Health, Xinjiang Medical University, Urumqi, China.
World Journal of Surgical Oncology +

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July 27, 2025

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July 27, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

A nomogram predicts survival for early-stage tongue squamous cell carcinoma (TSCC) patients. Postoperative radiotherapy (PORT) was linked to worse outcomes in specific patient subgroups, warranting cautious interpretation.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background

  • Early-stage tongue squamous cell carcinoma (TSCC) presents a need for accurate survival prediction.
  • Identifying factors influencing overall survival (OS) and cancer-specific survival (CSS) is crucial for treatment planning.

Purpose Of The Study

  • To develop and validate a nomogram for predicting OS and CSS in patients with early-stage TSCC (pT1-2N0M0).
  • To investigate the association between postoperative radiotherapy (PORT) and survival outcomes in this patient cohort.

Main Methods

  • Utilized data from 7,637 patients with pT1-2N0M0 TSCC from the SEER database (2000-2021).
  • Employed Kaplan-Meier analysis, Cox regression, and propensity score matching (PSM) for prognostic factor identification and outcome comparison.
  • Constructed and validated a nomogram using training and validation cohorts (2:1 ratio).

Main Results

  • Identified age, race, marital status, grade, tumor size, lymph node (LN) removed status, and PORT as independent prognostic factors for OS and CSS.
  • The nomogram demonstrated strong predictive performance in both training and validation cohorts.
  • After PSM, PORT was associated with worse OS and CSS, particularly in specific subgroups (e.g., younger, married, T1 stage, smaller tumors, no LN removal).

Conclusions

  • A SEER-based nomogram effectively predicts survival for early-stage TSCC patients.
  • PORT's association with poorer survival in certain subgroups requires cautious interpretation due to observational data limitations.
  • Further prospective studies with comprehensive clinical data are needed to guide individualized PORT decisions.

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