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Updated: Jun 19, 2026

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
Published on: March 6, 2009
Creation and evaluation of a combined pathology resident rotation in immunology, histocompatibility, and coagulation
Edward A Dent1, Harold C Sullivan1, Cheryl L Maier1
1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States.
Objective:
Clinical pathology curriculum assessment at our institution suggested improvements in coagulation, histocompatibility, and immunology. We created a 4-week rotation inclusive of these fields, and we describe here the curriculum and experience residents have had.
Methods:
Didactic lectures, assigned reading, time at the bench, online modules, and case study discussions were implemented. There were 2 weeks of morning activities dedicated to histocompatibility, while the other 2 weeks were dedicated to immunology. Afternoons were dedicated to special coagulation. Resident surveys and medical knowledge assessments were completed at the beginning and end of the rotation.
Results:
We included in this analysis 22 residents. The average knowledge quiz score before the rotation was 15.7 (48% [range, 8-23]) correct answers, while the average score after the rotation was 25 (76% [range, 19-29]), corresponding to a 28% increase in scores. On a Likert scale of 1 to 5, 88% of trainees ranked the rotation at a 4. After the rotation, residents felt more confident interpreting studies for the 3 subspecialties, particularly for special coagulation.
Conclusions:
Residents liked the rotation, and their evaluations demonstrate an increase in medical knowledge after the rotation. The training described here can be adapted to teach other compatible clinical pathology subspecialties.
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