Crosstalk between hippo and Wnt pathways in intestinal stem cells regeneration

Intestinal stem cell (ISC) regeneration is the key to maintaining intestinal homeostasis. The proliferation and differentiation of ISCs are regulated by the specific cells in the stem cell niche, and these cells mainly regulate ISC activity through secreting related ligands of various pathways, among which the Wnt pathway is the primary pathway regulating ISC regeneration, and the Hippo pathway plays an important role in controlling organ size and repairing injury. Accumulating evidence has identified that these two pathways closely cooperate to regulate the self-renewal and regeneration of ISCs, which has important significance in the maintenance of intestinal homeostasis and the treatment of intestinal disorders. Therefore, we provide an overview of the interaction of the Wnt and Hippo pathways in ISC regeneration and intestinal diseases, which not only sheds light on the mechanisms of maintaining intestinal homeostasis but also paves the way for novel therapeutic strategies for intestinal diseases.