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Relationship between cardiac implantable electronic devices and tricuspid regurgitation in the general population

  • 0Department of Medicine, University of California, San Francisco, San Francisco, California.
Heart Rhythm +

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July 27, 2025

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July 27, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Cardiac implantable electronic devices (CIED) increase the risk of tricuspid regurgitation (TR) and interventions. However, other cardiovascular conditions pose a greater risk than CIEDs for TR development.

Area Of Science

  • Cardiology
  • Medical Devices
  • Public Health

Background

  • Cardiac implantable electronic devices (CIED) with right ventricular leads can mechanically obstruct tricuspid valve leaflets.
  • This mechanical restriction may lead to clinically significant tricuspid regurgitation (TR).

Purpose Of The Study

  • To investigate the impact of CIED implantation on the incidence of new clinically relevant TR.
  • To assess the association between CIEDs and the need for tricuspid interventions in a large Californian population.

Main Methods

  • A longitudinal Cox proportional-hazards analysis was conducted using California's Department of Health Care Access and Information databases.
  • The study included adults receiving care between October 2015 and December 2020, excluding those with specific pre-existing heart conditions.
  • Outcomes analyzed were the development of TR and tricuspid valve interventions.

Main Results

  • CIED implantation was associated with a 65% higher risk of developing TR after multivariable adjustment.
  • Patients with CIEDs had a 3-fold increased risk of undergoing tricuspid intervention.
  • Other factors like heart failure and pulmonary hypertension presented a higher risk for TR than CIEDs.

Conclusions

  • CIED recipients face an elevated risk of TR and tricuspid interventions.
  • The increased risk associated with CIEDs is less pronounced compared to other major cardiovascular risk factors.

Keywords:

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