Self-healing hydrogels from hyaluronic acid and dialdehyde carboxymethyl cellulose for accelerated wound healing

This study aimed to introduce a bioresponsive and green hydrogel based on hyaluronic acid (HA) and dialdehyde carboxymethyl cellulose (DCMC) with remarkable potential for accelerating the wound healing process. Hydrogels made of freeze-thaw gelation were synthesized to entrap and deliver gallic acid (GA). The hydrogels were effortlessly engineered using hemiacetal interactions between HA and DCMC at proper pH and freeze-thaw cycle. The pore uniformity, mechanical strength, and thermostability can imply an appropriate degree of hemiacetal cross-link. The hydrogel revealed outstanding biocompatibility, flexibility, and self-healing properties, allowing it to uphold its form even over bodily movements. A considerable acceleration in wound closure was shown on day 10 (76.29 ± 4.08 %) compared to the control group (33.62 ± 6.24 %). Histopathological studies also demonstrated a decrease of inflammation, which can be linked to notable antioxidant and antibacterial features of the hydrogel. This research highlights the effectiveness of combining natural polymers and biocompatible cross-linker, offering a promising approach for developing advanced wound dressings.