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Updated: Sep 13, 2025

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Octenidine effectively reduces Candida auris colonisation on human skin.

Diana Cerbu1, Saskia Seiser1, Trinh Phan-Canh2

  • 1Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Scientific Reports
|July 27, 2025
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Summary

Octenidine-based antiseptics effectively reduce colonization by the critical pathogen Candida auris (C. auris) on human skin. This study shows octenidine

Keywords:
Candidozyma auris (formerly Candida auris)Antifungal stewardshipAntisepticsEx vivo modelHuman skin

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Area of Science:

  • Infectious Diseases
  • Dermatology
  • Antimicrobial Resistance

Background:

  • Candida auris (C. auris) is a critical priority pathogen identified by the WHO.
  • C. auris exhibits multi-drug resistance and significant skin tropism, posing a major health threat.
  • Effective strategies are needed to reduce C. auris colonization and healthcare-associated infections.

Purpose of the Study:

  • To evaluate the efficacy of commercial octenidine-based antiseptics against C. auris.
  • To assess the reduction of C. auris colonization on both intact and wounded human skin models.
  • To determine the in vitro antifungal activity of octenidine formulations against various C. auris strains.

Main Methods:

  • Utilized an ex vivo human skin model to simulate clinical contamination scenarios.
  • Applied two ready-to-use octenidine-based antiseptics post-contamination with planktonic C. auris.
  • Assessed fungal colonization using periodic acid-Schiff staining, microscopy (bright field and scanning electron), and CFU quantification.
  • Conducted in vitro biofilm assays with diverse C. auris strains, including drug-resistant variants.

Main Results:

  • Octenidine-based antiseptics significantly reduced C. auris viability on intact and wounded human skin.
  • Demonstrated nearly complete eradication of C. auris across tested strains in vitro.
  • Microscopy confirmed a substantial decrease in fungal burden on treated skin samples.

Conclusions:

  • Octenidine-based antiseptics show significant potential for reducing C. auris colonization on human skin.
  • These findings support the integration of octenidine products into infection prevention and control strategies.
  • The use of octenidine may enhance patient safety by mitigating C. auris transmission in healthcare settings.