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Physiological role of dehydroascorbic acid.

S Banerjee

    Indian Journal of Physiology and Pharmacology
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Dehydroascorbic acid (DHA) levels rise in blood and tissues during illness and stress, indicating L-ascorbic acid deficiency. High DHA may signal a need for vitamin C and influence cell division.

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    Area of Science:

    • Biochemistry
    • Cell Biology
    • Human Physiology

    Background:

    • Dehydroascorbic acid (DHA) is typically found in low concentrations in biological tissues.
    • Significant increases in DHA occur during various physiological and pathological states.

    Purpose of the Study:

    • To investigate the conditions associated with elevated dehydroascorbic acid levels.
    • To explore the relationship between dehydroascorbic acid, L-ascorbic acid, and glutathione.
    • To examine the potential role of dehydroascorbic acid in cell division.

    Main Methods:

    • Observational analysis of dehydroascorbic acid levels in blood and tissues.
    • Monitoring of L-ascorbic acid and glutathione levels concurrently.
    • Assessment of dehydroascorbic acid response to high-dose ascorbic acid administration.

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    Main Results:

    • Dehydroascorbic acid increases in infectious diseases, thyrotoxicosis, and after hormone injections (thyroxin, corticotropin, cortisone).
    • These conditions show a simultaneous decrease in L-ascorbic acid and glutathione.
    • Elevated dehydroascorbic acid levels decrease with high-dose ascorbic acid supplementation.
    • Accumulation of dehydroascorbic acid suggests ascorbic acid deficiency.

    Conclusions:

    • The ascorbate system is highly sensitive to physiological changes, suggesting a crucial biochemical role.
    • Increased dehydroascorbic acid accumulation may serve as a biomarker for ascorbic acid deficiency.
    • Dehydroascorbic acid is implicated in the control of cell division.