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Microbial Nutrition01:28

Microbial Nutrition

304
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
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Metabolism of Chemolithotrophs01:15

Metabolism of Chemolithotrophs

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Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
176
Environmental Applications of Microorganisms01:30

Environmental Applications of Microorganisms

260
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
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Factors Influencing Microbial Growth: pH01:29

Factors Influencing Microbial Growth: pH

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Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
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The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

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Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
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Carbon-dioxide Fixation01:28

Carbon-dioxide Fixation

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Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
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Related Experiment Video

Updated: Sep 13, 2025

Self-standing Electrochemical Set-up to Enrich Anode-respiring Bacteria On-site
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Self-standing Electrochemical Set-up to Enrich Anode-respiring Bacteria On-site

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Microbial metal physiology: ions to ecosystems.

John D Helmann1

  • 1Department of Microbiology, Cornell University, Ithaca, NY, USA. jdh9@cornell.edu.

Nature Reviews. Microbiology
|July 27, 2025
PubMed
Summary

Microorganisms must manage metal ion levels for survival, facing challenges from both scarcity and toxicity in diverse environments. Understanding microbial metal physiology offers solutions for ecosystem health, bioremediation, and pathogen control.

Area of Science:

  • Microbial Physiology
  • Environmental Microbiology
  • Biochemistry

Background:

  • Metal ions are essential for life, but their concentrations vary greatly across environments, leading to limitations or toxicities for microorganisms.
  • Microbial fitness is influenced by metal availability, impacting both commensal and pathogenic species within the human host and external ecosystems.
  • Metal homeostasis is crucial, requiring efficient import during deficiency and export during excess to prevent cellular damage.

Purpose of the Study:

  • To review the key processes of metal transport, trafficking, storage, and regulation in microorganisms.
  • To highlight how microorganisms adapt to survive in environments with varying metal concentrations, from limited to toxic levels.
  • To explore the potential applications of microbial metal physiology in ecosystem management, bioremediation, biomining, and combating bacterial pathogens.

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Main Methods:

  • Review of existing literature on microbial metal ion homeostasis.
  • Analysis of metalloregulatory systems and their associated regulons.
  • Case studies of microorganisms thriving in metal-limited or metal-toxic environments.

Main Results:

  • Metalloregulatory systems are central to microbial adaptation to metal availability fluctuations.
  • Analysis of these systems reveals critical transport, trafficking, and storage functions.
  • Insights into intracellular metal pools and processes affected by metal imbalance were gained.

Conclusions:

  • A comprehensive understanding of microbial metal physiology is essential for addressing environmental and health challenges.
  • Harnessing this knowledge can lead to improvements in ecosystem health, bioremediation strategies, and biomining applications.
  • Targeting microbial metal metabolism offers a route to control pathogenic bacterial growth.