Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...

Lineage Commitment

Lineage Commitment

Commitment is the process whereby stem cells:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation.

Cellular and molecular bioengineering·2025

Same author

Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.

Nature biomedical engineering·2025

Same author

Epigenetics of Hypertensive Nephropathy.

Biomedicines·2024

Same author

Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes.

Bioengineering (Basel, Switzerland)·2024

Same author

Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated <i>SMAD2</i> mutations.

bioRxiv : the preprint server for biology·2024

Same author

Fenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease.

International journal of molecular sciences·2024

Same journal

Genetic analysis of imaging-derived phenotypes.

Nature reviews. Genetics·2026

Same journal

Genetic origins and constraints of evolutionary innovation.

Nature reviews. Genetics·2026

Same journal

Single-cell four-omics with CHARM.

Nature reviews. Genetics·2026

Same journal

Molecular integration of seasonal temperature signals in flowering time control.

Nature reviews. Genetics·2026

Same journal

RBPscan measures protein-RNA interactions in living cells.

Nature reviews. Genetics·2026

Same journal

Revisiting retinal and macular degeneration in the genomics era.

Nature reviews. Genetics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 8, 2025

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

Decoding cell fate: human models reveal how SMAD2 variants shape development

Samira Musah^1,2,3,4,5

¹Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA. samira.musah@duke.edu.

Nature Reviews. Genetics

|July 27, 2025

Summary

No abstract available in PubMed .

More Related Videos

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Related Experiment Videos

Last Updated: Sep 8, 2025

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013