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Published on: July 21, 2018
FKBP10 expression and TP53 mutation predict prognosis and chemotherapy response in triple-negative breast cancer
Yan Li1,2, Chi Zhang1, Jian Chen1
1Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Background:
Triple-negative breast cancer (TNBC) lacks targeted therapies. FKBP10 contributes to oncogenesis and chemoresistance. We investigated FKBP10's prognostic value in TNBC.
Methods:
We retrospectively analyzed 190 TNBC patients receiving neoadjuvant chemotherapy. Patients were stratified by FKBP10 expression (median AOD cutoff) and TP53 status. Cox regression identified prognostic factors for disease-free survival (DFS) and pathological complete response (pCR).
Results:
34% achieved pCR. High FKBP10 expression correlated with worse DFS (HR = 0.50, 95%CI: 0.26-0.96, P = 0.03). Independent predictors of DFS included: N-stage (P = 0.021), age (P = 0.027), FKBP10/TP53 co-occurrence (P = 0.020), and pCR status (P = 0.005). FKBP10/TP53 co-occurrence predicted poor chemotherapy response (OR = 0.413, P = 0.016).
Conclusion:
FKBP10 overexpression with TP53 mutation predicts poor prognosis and chemoresistance in TNBC. These biomarkers may guide treatment decisions, though prospective validation is needed.
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