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Related Experiment Video

Updated: Apr 30, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Three-Dimensional Single-Shot CEST Imaging at 3T Based on True FISP Readout.

Yupeng Wu1, Qifan Pang1, Zhichao Wang2

  • 1Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China.

NMR in Biomedicine
|July 27, 2025
PubMed
Summary
This summary is machine-generated.

A new 3D Chemical Exchange Saturation Transfer (CEST) imaging sequence using True fast imaging with steady-state precession (True FISP) offers higher signal-to-noise ratio (SNR) and improved image quality compared to traditional methods for brain tumor imaging.

Keywords:
CESTbalanced steady state free precession (bSSFP)fast imagingthree‐dimensional (3D)true fast imaging with steady‐state precession (True FISP)

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Magnetic Resonance Imaging

Background:

  • 3D Chemical Exchange Saturation Transfer (CEST) imaging is crucial for analyzing biological processes.
  • Existing methods like FLASH and EPI have limitations including low SNR and image distortion.
  • There is a need for advanced imaging sequences to improve CEST acquisition quality.

Purpose of the Study:

  • To develop and validate a novel 3D single-shot CEST sequence using True fast imaging with steady-state precession (True FISP) readout.
  • To compare the performance of the True FISP-based CEST sequence against the conventional FLASH sequence.
  • To assess the potential of True FISP for high-quality, time-efficient CEST imaging in clinical settings.

Main Methods:

  • Developed a 3D single-shot CEST sequence utilizing True FISP (balanced steady state free precession) readout.
  • Optimized scanning parameters through simulations.
  • Validated the sequence in an egg white phantom, 10 healthy volunteers, and 2 brain tumor patients on a 3T scanner.
  • Compared True FISP-CEST with FLASH-CEST regarding SNR and contrast, maintaining identical acquisition parameters.

Main Results:

  • Simulations showed significantly greater CEST signal with True FISP compared to FLASH.
  • Phantom studies revealed 68.3% and 57.0% higher SNR for APTw and NOE images with True FISP, respectively.
  • Healthy volunteers demonstrated an 84% increase in mean temporal SNR with True FISP.
  • True FISP-CEST images displayed more detailed brain structures in both healthy subjects and tumor patients.

Conclusions:

  • The True FISP-based 3D single-shot CEST sequence provides superior SNR and image quality compared to FLASH.
  • The sequence effectively visualizes detailed brain tissue structures, benefiting both healthy individuals and patients with brain tumors.
  • True FISP offers a promising approach for fast, high-quality 3D CEST imaging in clinical applications.