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Memory-Associated Immediate Early Genes: Roles in Synaptic Function, Memory Processes, and Neurological Diseases.

Zafar U Khan1,2,3, Marta Carretero-Rey4,5, Cristina A Muñoz de León-López4,5

  • 1Laboratory of Neurobiology, Centro de Investigaciones Medico Sanitarias (CIMES), University of Malaga, University of Malaga, Campus Teatinos s/n, Malaga, 29010, Spain. zkhan@uma.es.

Molecular Neurobiology
|July 27, 2025
PubMed
Summary

Immediate early genes (IEGs) are crucial for learning and memory by regulating neuronal activity and synaptic plasticity. Dysregulation of IEGs is linked to cognitive decline and brain diseases, highlighting their importance in brain health.

Keywords:
AP1Aging and neurological diseasesArc (Arg3.1)BDNFCFosCJunHomer1aImmediate early genesLTP and LTDMemoryNarpNpas4, Zif268 (Egr1)Synaptic plasticity

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