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Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Related Experiment Video

Updated: Sep 13, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

348

Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder.

Lachlan Webb1, Luke Hearne2, Ye E Tian3

  • 1Clinical Brain Networks Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|July 27, 2025
PubMed
Summary

This study reveals altered striatal connectivity in obsessive-compulsive disorder (OCD). Changes in striatal gradient topology correlate with symptom severity, suggesting potential therapeutic targets for OCD.

Keywords:
CompulsivityGradientsLongitudinal changesObsessive-compulsive disorderfMRI

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Computational Neuroscience

Background:

  • Obsessive-compulsive disorder (OCD) involves altered functional connectivity within the striatum.
  • Previous research on striatal changes in OCD is incomplete.
  • Striatal gradients offer a novel method to map functional organization.

Purpose of the Study:

  • To investigate differences in striatal gradient topology between individuals with OCD and controls.
  • To explore the relationship between striatal gradient changes and OCD symptom fluctuations over time.

Main Methods:

  • Calculated spatial striatal gradients from resting-state and task-based fMRI data in 52 individuals with OCD and 45 controls.
  • Utilized longitudinal data from 47 individuals with OCD to assess changes in gradient topology.
  • Examined gradients during a threat-safety reversal task.

Main Results:

  • Found significant group differences in resting-state striatal gradient topology, particularly in the putamen and caudate.
  • Observed that individuals with symptom improvement showed gradient changes aligning with controls.
  • Identified a group difference in safety-reversal gradient topology within the right nucleus accumbens and putamen.

Conclusions:

  • Striatal connectivity alterations, specifically in gradient topology, play a key role in OCD symptom expression.
  • Findings support the need for research into neural mechanisms of striatal reorganization.
  • Encourages the development of therapies targeting striato-cortical plasticity for OCD treatment.