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Updated: Sep 13, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Controversial Nomenclature in Peptide Synthesis: A Call for Clarity
Anamika Sharma1, Ashish Kumar1,2, Beatriz G de la Torre2
1Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Abstract:
Various approaches to make peptides have been adopted globally owing to their high demand. The three main approaches commonly used for this purpose are solution synthesis, also called classical solution-phase peptide synthesis (CSPS), solid-phase peptide synthesis (SPPS), and liquid-phase peptide synthesis (LPPS). Each method offers unique advantages: CSPS for scalability, SPPS for automation and efficiency, and LPPS for combining solution-phase simplicity with iterative synthesis using soluble tags.
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Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
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