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Updated: Sep 13, 2025
10:15
Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
25.0K
Management of Neutropenic Fever in Persons with Cancer
1Columbia University School of Nursing, 560 West 168th Street, New York, NY 10032, USA.
The Nursing Clinics of North America
|July 27, 2025
Summary
Neutropenic fever, a critical condition defined by fever and low neutrophil counts, demands immediate medical attention. Prompt evaluation and broad-spectrum antibiotics within one hour are crucial for managing this emergency.
Area of Science:
- Oncology
- Hematology
- Infectious Diseases
Background:
- Neutropenic fever is a serious complication in cancer patients undergoing chemotherapy.
- It is characterized by fever and a low absolute neutrophil count (ANC).
- Prompt management is critical to prevent severe outcomes.
Purpose of the Study:
- To define neutropenic fever and outline its immediate management.
- To emphasize the importance of timely antibiotic administration.
- To introduce risk stratification tools for febrile neutropenia.
Main Methods:
- Definition of neutropenic fever: single oral temperature ≥ 38.3°C or sustained ≥ 38.0°C with ANC < 0.5 × 10⁹/L.
- Initiation of broad-spectrum antibiotics within 1 hour of presentation.
- Collection of lab work and blood cultures before antibiotic initiation.
- Risk assessment using validated scoring systems (e.g., MASCC, CISNE).
Main Results:
- Neutropenic fever requires urgent evaluation and management.
- Broad-spectrum antibiotics are the cornerstone of treatment.
- Risk stratification aids in identifying patients at high risk for complications.
Conclusions:
- Early recognition and treatment of neutropenic fever are vital.
- Adherence to management guidelines improves patient outcomes.
- Utilizing scoring systems enhances clinical decision-making in febrile neutropenia.
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