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Factors Associated With Potentially Inappropriate Medication Use and Deprescribing Among Patients Receiving
Yi-Chen Wu1, Yu-Chang Yang2, Meng-Sui Lee3
1The Department of Pharmacy, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan.
The American Journal of Hospice & Palliative Care
|July 28, 2025
Summary
Potentially inappropriate medications (PIMs) are common in home hospice care. Patients receiving nasogastric tube feeding were less likely to have PIMs deprescribed, highlighting a need for improved medication safety.
Area of Science:
- Geriatrics
- Palliative Care
- Clinical Pharmacy
Background:
- Potentially inappropriate medications (PIMs) pose risks, especially in vulnerable populations like home hospice patients.
- Optimizing medication regimens in palliative care is crucial for patient well-being and safety.
Purpose of the Study:
- To investigate factors linked to PIM use and deprescribing in home hospice patients in Taipei.
- To identify specific PIMs and associated risk factors using OncPal and STOPPFrail criteria.
Main Methods:
- Analysis of 101 home hospice patients from Taipei City hospital (2016-2022).
- Utilized OncPal and STOPPFrail version 2 criteria for PIM identification.
- Employed logistic regression and Cox proportional hazards regression for data analysis.
Main Results:
- Approximately 50% of patients used at least one PIM; excessive polypharmacy (41.6%) and nasogastric tube feeding (29.7%) were common.
- Excessive polypharmacy significantly correlated with PIM use (aORs 5.87-10.39).
- Nasogastric tube feeding showed a negative association with PIM deprescribing (aHRs 0.08-0.23).
Conclusions:
- A high prevalence of PIMs exists in home hospice settings, necessitating targeted interventions.
- Deprescribing PIMs is less likely in patients receiving nasogastric tube feeding.
- Further research is warranted to enhance medication safety and minimize PIMs in this population.
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