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The Impact of Time-in-Target Range for Systolic Blood Pressure on Left Ventricular Hypertrophy

Jianjiao Wang1,2, Wen Li3, Gui Man4

  • 1Graduate School of the First Clinical Medical School, Hebei North University, Zhangjiakou, Hebei, China.

American Journal of Hypertension
|July 28, 2025
PubMed

Insights

Higher systolic blood pressure time-in-target range (SBP-TTR) is linked to reduced left ventricular hypertrophy (LVH) risk. Maintaining SBP-TTR within 110-130 mmHg offers greater LVH risk reduction than the 120-140 mmHg range.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Medicine

Background:

  • Investigating the relationship between systolic blood pressure time-in-target range (SBP-TTR) and left ventricular hypertrophy (LVH).
  • Understanding the impact of blood pressure control on cardiac structure and function.

Purpose of the Study:

  • To determine the association between different SBP-TTR levels and the risk of developing LVH.
  • To compare the efficacy of two target SBP ranges (120-140 mmHg vs. 110-130 mmHg) in mitigating LVH risk.

Main Methods:

  • Analysis of data from 33,818 participants in the Kailuan Study (2006-2020) with echocardiography results.
  • Calculation of SBP-TTR using linear interpolation for target ranges of 120-140 mmHg and 110-130 mmHg.
  • Utilizing Poisson regression models to assess the relative risk (RR) of LVH associated with SBP-TTR.

Main Results:

  • A higher SBP-TTR (75%-100%) within the 120-140 mmHg range was associated with a reduced risk of LVH (RR: 0.94).
  • Within the 110-130 mmHg range, increased SBP-TTR showed significant LVH risk reduction across multiple categories (25%-50%, 50%-75%, 75%-100%).
  • Restricted cubic spline analysis confirmed a linear, dose-response relationship between SBP-TTR and LVH risk.

Conclusions:

  • Increased SBP-TTR is significantly associated with a decreased risk of left ventricular hypertrophy.
  • A stricter SBP target range of 110-130 mmHg demonstrates a more effective reduction in LVH risk compared to a 120-140 mmHg range.
Abstract

Keywords:
Kailuan studyblood pressurehypertensionleft ventricular hypertrophytime-in-target range for systolic blood pressure

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