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Prognostic model based on KCNK family genes for predicting prognosis and immunotherapy response in lung
Li Xu1, Danting Zheng2, Jisong Zhang1
1Department of Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Abstract:
The tow-pore domain (KCNK) potassium channel family is associated with tumor progression, but its prognostic value in lung adenocarcinoma (LUAD) remains unclear. In this study, we integrated data from the TCGA and GEO databases to identify 9 KCNK-related differentially expressed genes, and based on this, we classified two molecular subtypes with significantly different prognoses. A 11-gene prognostic model with independent prognostic value was constructed through regression analysis. Immuno-analysis revealed that the low-risk group had stronger immune infiltration and might be more suitable for immunotherapy. These findings reveal the prognostic significance of the KCNK genes and provide a reference for immunotherapy.
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