Mandibular Reconstruction Using Freeze-Dried Cortical and Cancellous Allografts and Titanium Locking Miniplates in 3...

Area of Science:

• Veterinary Surgery
• Oral and Maxillofacial Surgery
• Biomaterials Science

Background:

• Critical-sized mandibular defects pose significant reconstruction challenges in veterinary medicine.
• Current repair methods may have limitations in achieving complete bone integration and functional restoration.

Purpose of the Study:

• To evaluate the efficacy of cortical allografts, cancellous allografts (with or without recombinant human platelet-derived growth factor-BB), and titanium locking plates in repairing critical-sized mandibular defects in dogs.
• To assess the bone integration and overall success of these reconstructive techniques.

Main Methods:

• A case series involving 4 canine mandibles (3 patients) with critical-sized defects due to oncologic surgery or chronic nonunion fractures.
• Utilized cortical allografts, cancellous allografts with/without recombinant human platelet-derived growth factor-BB, and titanium locking plates.
• Employed various intraoperative techniques to maintain occlusion.

Main Results:

• Postoperative imaging confirmed successful integration of the allografts with the host bone in all treated canine mandibles.
• The reconstructive techniques demonstrated validity in addressing critical-sized defects.

Conclusions:

• Allograft transplantation combined with titanium plates is a viable and effective method for reconstructing critical-sized mandibular defects in dogs.
• This approach shows promise for improving outcomes in canine patients requiring mandibular repair.