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Meropenem/Vaborbactam in Pediatrics: 2 Cases of CRE Intraabdominal Infection

Ugene Sano1, Rachel Meyers1,2, Uzma Hasan1

  • 1Departments of Pharmacy (US, RM, SS) and Pediatric Infectious Disease (UH), Cooperman Barnabas Medical Center, Livingston, NJ.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|July 28, 2025
PubMed

Insights

Meropenem/vaborbactam showed safe and effective use in two pediatric patients with carbapenem-resistant Enterobacterales (CRE) intraabdominal abscesses. Further research is needed to establish optimal use and safety in pediatric populations.

Area of Science:

  • Infectious Diseases
  • Pediatric Pharmacology
  • Antimicrobial Resistance

Background:

  • Meropenem/vaborbactam is an antibiotic combination for extensively drug-resistant infections.
  • Approved for adult complicated urinary tract infections, pediatric data are limited.
  • Carbapenem-resistant Enterobacterales (CRE) pose a significant treatment challenge.

Purpose of the Study:

  • To describe the use of meropenem/vaborbactam in pediatric patients with CRE infections.
  • To evaluate the safety and efficacy of meropenem/vaborbactam in this population.

Main Methods:

  • Case series involving two pediatric patients (ages 11 and 15).
  • Patients presented with intraabdominal abscesses caused by CRE.
  • Treatment involved meropenem/vaborbactam administration.

Main Results:

  • Both pediatric patients experienced clinical improvement.
  • No complications were reported during follow-up after antibiotic course completion.
  • Meropenem/vaborbactam demonstrated safe and effective treatment in these cases.

Conclusions:

  • Meropenem/vaborbactam can be safely and effectively used in pediatric patients for CRE infections.
  • Additional data are required to determine the optimal use and safety profile in pediatric populations.
Keywords:
case series.intraabdominal abscessintraabdominal infectionmeropenem vaborbactampediatric

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