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Meropenem/Vaborbactam in Pediatrics: 2 Cases of CRE Intraabdominal Infection
Ugene Sano1, Rachel Meyers1,2, Uzma Hasan1
1Departments of Pharmacy (US, RM, SS) and Pediatric Infectious Disease (UH), Cooperman Barnabas Medical Center, Livingston, NJ.
Summary
Meropenem/vaborbactam showed safe and effective use in two pediatric patients with carbapenem-resistant Enterobacterales (CRE) intraabdominal abscesses. Further research is needed to establish optimal use and safety in pediatric populations.
Area of Science:
- Infectious Diseases
- Pediatric Pharmacology
- Antimicrobial Resistance
Background:
- Meropenem/vaborbactam is an antibiotic combination for extensively drug-resistant infections.
- Approved for adult complicated urinary tract infections, pediatric data are limited.
- Carbapenem-resistant Enterobacterales (CRE) pose a significant treatment challenge.
Purpose of the Study:
- To describe the use of meropenem/vaborbactam in pediatric patients with CRE infections.
- To evaluate the safety and efficacy of meropenem/vaborbactam in this population.
Main Methods:
- Case series involving two pediatric patients (ages 11 and 15).
- Patients presented with intraabdominal abscesses caused by CRE.
- Treatment involved meropenem/vaborbactam administration.
Main Results:
- Both pediatric patients experienced clinical improvement.
- No complications were reported during follow-up after antibiotic course completion.
- Meropenem/vaborbactam demonstrated safe and effective treatment in these cases.
Conclusions:
- Meropenem/vaborbactam can be safely and effectively used in pediatric patients for CRE infections.
- Additional data are required to determine the optimal use and safety profile in pediatric populations.
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