Peptide Drug: Design and Clinical Applications

Area of Science:

• Biochemistry
• Molecular Biology
• Pharmacology

Background:

• Peptide drugs are valuable in clinical settings due to their biocompatibility and specificity.
• Peptide drugs modulate diseases via metabolic reprogramming and immune responses through cell signaling.
• Circular RNAs (circRNAs) are emerging as sources of functional polypeptides.

Purpose of the Study:

• To review recent advances in peptide drugs for disease treatment.
• To focus on circRNA-encoded polypeptides as a novel drug development avenue.
• To explore mechanisms, delivery, modification, and challenges of circRNA-based peptide drugs.

Main Methods:

• Systematic literature review of peptide drugs and circRNA research.
• Analysis of functional mechanisms of peptide drugs in disease.
• Examination of circRNA encoding and polypeptide applications.

Main Results:

• Peptide drugs play key roles in metabolic reprogramming and immune modulation.
• circRNAs can encode functional polypeptides with potential therapeutic applications.
• Current research highlights challenges in developing circRNA-based peptide drugs.

Conclusions:

• circRNA-encoded polypeptides represent a promising frontier for peptide drug discovery.
• Understanding circRNA encoding mechanisms is crucial for therapeutic development.
• This review provides insights for future circRNA-based polypeptide drug design.