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Interplay of rheumatoid arthritis and cardiovascular disease: Insights and prospects

Anastasia V Poznyak1, Nikolay A Orekhov2, Alexey V Churov2,3

  • 1Institute for Atherosclerosis Research, Moscow, Russia.

SAGE Open Medicine
|July 28, 2025
PubMed

Insights

Rheumatoid arthritis (RA) patients face higher cardiovascular disease (CVD) risk from chronic inflammation. Standard risk assessments often underestimate this, necessitating personalized strategies for better patient outcomes.

Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is a chronic inflammatory condition.
  • RA significantly elevates the risk of cardiovascular disease (CVD).
  • Systemic inflammation in RA is a key driver of CVD.

Purpose of the Study:

  • To critically analyze the relationship between RA and CVD.
  • To elucidate mechanisms linking RA inflammation to cardiovascular risk.
  • To evaluate current treatment strategies for mitigating CVD in RA patients.

Main Methods:

  • Systematic literature review.
  • Evaluation of conventional CVD risk factors in RA.
  • Analysis of inflammation-specific markers impacting cardiovascular outcomes.

Main Results:

  • Chronic inflammation in RA substantially increases CVD risk.
  • Standard CVD risk assessment protocols often underestimate risk in RA patients.
  • Disease-modifying antirheumatic drugs (DMARDs) like methotrexate may reduce CVD risk.

Conclusions:

  • Current CVD risk assessment in RA is often inadequate.
  • Integrating novel risk factors and personalized management is crucial.
  • Improved understanding and tailored strategies can enhance outcomes for RA patients at high CVD risk.

Keywords:
Cardiovascularrheumatology/clinical immunology

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