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Updated: Sep 13, 2025
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Clinical profile, prevalence, and burden of chronic spontaneous urticaria in the United States
Weily Soong1, Dhaval Patil2, Jonathan Rodrigues2
1AllerVie Health-Alabama Allergy & Asthma Center, Clinical Research Center of Alabama, Birmingham, AL, USA.
Background:
Data on the prevalence and burden of chronic spontaneous urticaria (CSU) are limited in the United States (US).
Objective:
To estimate the burden, clinical profile, and prevalence of diagnosed CSU in the United States.
Methods:
Data from respondents with physician-diagnosed CSU were collected from the 2019 National Health and Wellness Survey (NHWS). Outcomes assessed included diagnosed CSU prevalence, demographics, clinical profile, and burden using the 36-item Short Form Survey version 2 (SF-36v2; physical and mental component summary [PCS and MCS] scores), Short-Form 6 Dimension (SF-6D) and EuroQol-5 Dimension (EQ-5D) utility scores, Dermatology Life Quality Index (DLQI), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 (GAD-7), Work Productivity and Activity Impairment (WPAI) questionnaire, and healthcare resource utilization over the past 6 months.
Results:
Among 74,994 respondents, 815 reported physician-diagnosed chronic urticaria, with 635 (77.9%) having CSU. The weighted prevalence (95% confidence interval) of diagnosed CSU was 0.78% (0.78%-0.78%). The mean (standard deviation [SD]) age at diagnosis was 37.0 (17.1) years, and 51.7% of respondents were female. Lower (worse) MCS and PCS scores were observed than in the overall NHWS population. The mean (SD) SF-6D and EQ-5D health utility scores were 0.54 (0.14) and 0.62 (0.34), respectively. The mean (SD) DLQI score was 13.8 (11.2), with more than 74.0% of respondents reporting anxiety (GAD-7 ≥5) and depression (PHQ-9 ≥5). Mean percent (SD) scores for absenteeism, presenteeism, overall work impairment, and activity impairment were 36.5% (26.1), 67.2% (34.9), 73.1% (34.2), and 62.6% (34.1), respectively. The percentage of patients visiting any healthcare provider, an emergency department, or requiring hospitalization was 96.5%, 60.2%, and 55.9%, respectively.
Conclusion:
This real-world study reveals a higher prevalence of diagnosed CSU in the United States than previously reported, along with significant humanistic and economic burdens.
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