MRI-Derived Tumor Characteristics As Prognostic Indicators in Prostate Cancer With Bone Metastases: A Preliminary...

Area of Science:

• Radiology
• Oncology
• Medical Imaging

Background:

• Prostate cancer (PCa) assessment relies on MRI locally.
• Prognostic value of MRI in metastatic PCa is unclear.
• Bone metastases prognosis needs better predictors.

Purpose of the Study:

• Investigate pretreatment MRI for predicting survival.
• Assess MRI's role in disease progression for metastatic PCa.
• Correlate MRI findings with outcomes in bone-metastatic PCa.

Main Methods:

• Retrospective study of 19 bone-metastatic PCa patients.
• Analyzed MRI parameters: maximum tumor diameter (MTD), normalized mean apparent diffusion coefficient (nADCmean).
• Used Kaplan-Meier, log-rank tests, and Cox regression for survival and progression analyses.

Main Results:

• MTD ≥49 mm correlated with shorter overall survival (p=0.015).
• Higher nADCmean (≥0.19) predicted disease progression (p=0.031).
• Gleason score, PSA density, and T stage showed no significant prognostic value.

Conclusions:

• Pretreatment MRI MTD is a prognostic factor for overall survival in metastatic PCa.
• Higher nADCmean on MRI may indicate disease progression.
• MRI parameters offer potential for risk stratification and treatment planning in metastatic PCa.