Related Experiment Video
Updated: Sep 13, 2025

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
Intraoperative Resistance to Atracurium in a Geriatric Patient on Donepezil: A Case Report
Niruba C1, Reshmita Gandhi1, Gayathri Ramesh1
1Anesthesiology, Sree Balaji Medical College and Hospital, Chennai, IND.
Abstract:
We report the case of an 84-year-old male with dementia on chronic donepezil therapy who demonstrated resistance to the non-depolarizing neuromuscular blocker atracurium during general anesthesia for orthopedic surgery. Anesthesia was successfully managed using multimodal, opioid-free techniques. The case highlights an interaction between an acetylcholinesterase inhibitor and a neuromuscular blocking agent, emphasizing the need for awareness of such interactions in elderly patients. It also underscores the importance of conducting a preoperative medication review and individualized anesthetic planning in geriatric populations.
More Related Videos
09:11Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
Published on: February 23, 2016
08:50Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
Published on: June 25, 2013
Related Concept Videos
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...
Depolarizing Blockers: Pharmocokinetics
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Alzheimer's Disease: Treatment
Skeletal Muscle Relaxants: Therapeutic Uses