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Selective Toxicity of Iron, Manganese Oxide Nanostructure and Laser Wave on Colorectal and Breast Cancer Cell
Aysan Mansournia1, Nasim Nobari1, Fatemeh Ghanbary2
1Department of Physic, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
Background:
Cancer is a deadly and multifaceted disease that poses a significant challenge to treatment due to its heterogeneity and ability to adapt and evolve. Despite advancements in research and medicine, the development of effective treatment options remains a major obstacle in the battle against cancer. Manganese oxide (MnO) and iron (III) oxide (Fe2O3) nanoparticles (NPs) are increasingly used for numerous new applications in modern industrial sectors. However, the toxic and treatment impact of MnO and Fe2O3 NPs has not been clearly elucidated on human cell lines at the cellular and molecular levels.
Objectives:
This study aimed to assess the potential cytotoxic effect of combining infrared (IR) laser therapy with MnO and Fe2O3 nanoparticles on breast and colorectal cancer cells for cancer treatment.
Methods:
We treated the cancer cells with MnO and Fe2O3 NPs and then exposed them to IR radiation for 6, 12, 24, 48, and 72 hours to investigate the effectiveness of this cancer treatment approach. To evaluate cytotoxicity, we conducted assessments on Skbr3 and HT29 cancer cells, both individually and in combination, using various methods.
Results:
The findings indicate that despite the inherent toxicity of NPs and IR laser radiation on cancer cells, the utilization of MnO and Fe2O3 NPs in conjunction with IR laser radiation treatment had the highest cytotoxic impact on cancer cells.
Conclusions:
These findings suggest that using MnO and Fe2O3 NPs in combination with IR laser therapy has great potential as an effective method for reducing the population of cancer cells.This revision maintains the original content while ensuring clarity and adherence to the AMA style guidelines.
Insights
Combining manganese oxide (MnO) and iron (III) oxide (Fe2O3) nanoparticles with infrared laser therapy shows significant potential for reducing cancer cell populations. This novel approach enhances cytotoxic effects on breast and colorectal cancer cells.
Area of Science:
- Nanotechnology in oncology
- Biomedical applications of nanoparticles
- Laser-based cancer therapy
Background:
- Cancer's heterogeneity and adaptability present significant treatment challenges.
- Manganese oxide (MnO) and iron (III) oxide (Fe2O3) nanoparticles (NPs) have diverse industrial applications.
- The precise impact of MnO and Fe2O3 NPs on human cancer cells requires further elucidation.
Purpose of the Study:
- To evaluate the cytotoxic effects of combined infrared (IR) laser therapy and MnO/Fe2O3 NPs on cancer cells.
- To assess the efficacy of this combined approach for breast and colorectal cancer treatment.
Main Methods:
- Treatment of Skbr3 (breast) and HT29 (colorectal) cancer cells with MnO and Fe2O3 NPs.
- Exposure of treated cells to IR laser radiation for varying durations (6-72 hours).
- Comprehensive cytotoxicity assessments on cancer cell lines.
Main Results:
- Both NPs and IR laser radiation exhibited inherent toxicity to cancer cells.
- The combination of MnO/Fe2O3 NPs with IR laser therapy demonstrated the highest cytotoxic impact.
- Synergistic effects observed in reducing cancer cell viability.
Conclusions:
- Combined IR laser therapy and MnO/Fe2O3 NPs show promise for cancer treatment.
- This approach effectively reduces cancer cell populations.
- Further research into nanoparticle-IR laser therapy is warranted for clinical applications.
