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Published on: July 19, 2024
Cardiovascular implications of MASLD: overview of the evidence
Belend Ismail1, Puria Nabilou1, Lise Lotte Gluud1,2
1Gastro Unit, Medical Division, Copenhagen University Hospital, Hvidovre, Denmark.
Background:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and encompasses a spectrum from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), with potential progression to advanced fibrosis and cirrhosis.
Objective:
This review provides an overview of the link between MASLD and cardiovascular disease.
Results:
MASLD is closely linked to metabolic syndrome (MS) and cardiovascular disease, evidenced by increased coronary artery calcification, carotid intima-media thickness, epicardial adipose tissue, and pulse wave velocity, along with decreased flow-mediated dilation. These cardiovascular complications significantly heighten the risk of cardiovascular events and overall mortality.
Conclusion:
MASLD seems to be an independent cardiovascular risk factor, but further studies are warranted to clarify the distinct impacts of MASLD stages and their interplay with MS on cardiovascular outcomes.
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