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Updated: Sep 13, 2025
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Palladium-catalyzed in vivo bioorthogonal activation of N,N-dialkyl-α-hydroxymethyl acrylamide for efficient payload
Ruipeng Shen1,2, Baoxin Zhang2, Jirong Liu2
1School of Chemistry and Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu 210094, China. fangjg@njust.edu.cn.
Abstract:
The use of drug carriers plays a crucial role in ensuring the stable circulation of therapeutic agents within biological systems and their targeted delivery to specific sites, thereby enabling precise drug treatment. In this study, we developed a novel drug release carrier based on the structure of α-hydroxymethyl acrylamide. This carrier is capable of rapidly cleaving bonds and releasing the active payload (>90%) under the catalysis of the Pd (0) complex. When conjugated with the drug, the carrier demonstrated significant antitumor efficacy in a mouse tumor model. Overall, this innovative "click to release" chemistry exhibits fast kinetics and high efficiency, offering a promising new approach for drug delivery and prodrug release.
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