Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CRISPR-Cas-Based Platform for Single-Step Quantification of Monoclonal Antibodies at Point-of-Care.

ACS sensors·2026

Same author

Atomic structures of medin and Aβ fibrils reveal polymorphic remodeling in mixed amyloid systems.

Nature communications·2026

Same author

Cracking the code of native amyloid fibrils: advances and next steps to enable pathology-informed therapeutic and diagnostic.

Nature structural & molecular biology·2026

Same author

Metasurface-enhanced mid-infrared imaging spectroscopy with broadband quantum cascade lasers.

Nature communications·2026

Same author

A genomics health strategy for the Arabian Gulf.

Nature medicine·2026

Same author

Kinetic Profiling in One-Step Digital Immunoassays Enables Multiplex Quantification across an Ultrabroad Dynamic Range.

Journal of the American Chemical Society·2026

Same journal

Multi-tissue Metabolic GWAS and Drought-Responsive Multi-omics Reveal the Genetic Basis of the Quinoa Metabolome.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Bioinspired Multifunctional Flexible C-SiC Fibrous Aerogel for Superior Electromagnetic Interference Shielding Under Extreme Environments.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

From Chatbots to Co-Scientists: The Impact of Knowledge-Generating AI (AI 4.0) on Healthcare and Research.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Cobalt Single-Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Ultrafast Optoacoustics Reveals Intricate 3D Anisotropic Elasticity in Nanocrystalline Membranes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 7, 2026

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Published on: May 23, 2019

Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for

Deepthy Kavungal^1,2, Enzo Morro², Senthil T Kumar^2,3

¹Bionanophotonic Systems Laboratory (BIOS), Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|July 28, 2025

Summary

This summary is machine-generated.

This study introduces a novel nanoplasmonic sensor for high-throughput drug screening to combat neurodegenerative diseases (NDDs). The sensor efficiently detects protein aggregation, offering a promising tool for developing new NDDs therapeutics.

Keywords:

alpha‐synuclein high‐throughput screening infrared spectroscopy metasurfaces microarray neurodegenerative diseases plasmonics

More Related Videos

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Published on: September 12, 2019

Related Experiment Videos

Last Updated: May 7, 2026

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Using Near-infrared Fluorescence and High-resolution Scanning to Measure Protein Expression in the Rodent Brain

Published on: May 23, 2019

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Published on: September 12, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Neuroscience

Background:

Protein misfolding into β-sheet-rich fibrils is a hallmark of neurodegenerative diseases (NDDs).
Current drug screening methods for inhibiting protein aggregation are limited.
Early intervention requires efficient identification and screening of therapeutic compounds.

Purpose of the Study:

To develop a novel nanoplasmonic infrared microarray sensor for label-free, high-throughput drug screening.
To enable early disease intervention by detecting structural protein biomarkers in NDDs.
To overcome limitations of conventional drug screening assays.

Main Methods:

Utilized 2D arrays of nanoplasmonic units in micropatterned microwells for protein sensing.
Integrated ultra-compact 48, 96, and 384 microwell designs for flexibility.
Employed in situ measurement for secondary structural analysis of protein aggregation.

Main Results:

Achieved high-throughput protein sensing with low sample volume (2 nL) and high sensitivity (100 pg/mL).
Validated drug screening capability by assessing inhibition of α-synuclein (aSyn) aggregation.
Successfully detected protein oligomers and fibrils, outperforming conventional fluorescence assays.

Conclusions:

The nanoplasmonic microarray sensor is a promising advancement for NDDs research.
Offers a sensitive and rapid platform for label-free drug screening.
Facilitates the development of novel therapeutics for neurodegenerative diseases.