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Updated: Sep 13, 2025
07:11
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Right Ventricular Function and Its Association With Outcomes in Advanced Heart Failure
Kyle Steiger1, Naba Farooqui2, Jill M Killian3
1Department of Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address: https://twitter.com/KyleGSteiger.
Mayo Clinic Proceedings
|July 28, 2025
Summary
In advanced heart failure, moderate to severe right ventricular dysfunction is common and linked to higher death risks. However, it does not significantly impact hospitalization rates in these patients.
Area of Science:
- Cardiology
- Heart Failure Research
- Echocardiography
Background:
- Right ventricular (RV) function is crucial in heart failure management.
- Assessing RV function in advanced (Stage D) heart failure is vital for prognosis.
- Understanding RV dysfunction correlates and outcomes is essential for patient care.
Purpose of the Study:
- To determine clinical factors associated with right ventricular function in advanced heart failure.
- To investigate the relationship between RV function and mortality/hospitalization risks in this population.
Main Methods:
- Retrospective cohort study of 925 advanced heart failure patients (2007-2018).
- RV function assessed via echocardiography and categorized (normal, mild, moderate-to-severe dysfunction).
- Cox and Andersen-Gill models analyzed associations with death and hospitalization risks.
Main Results:
- 71% of patients exhibited some degree of RV dysfunction.
- Moderate to severe RV dysfunction was linked to increased all-cause (aHR 1.30) and cardiovascular mortality (aHR 1.32).
- No significant association found between RV function and hospitalization risk.
Conclusions:
- Right ventricular dysfunction is prevalent in advanced heart failure, worsening with reduced left ventricular ejection fraction.
- Moderate to severe RV dysfunction predicts higher mortality but not hospitalization.
- RV function assessment is critical for risk stratification in advanced heart failure.
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