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Neuronal and network resonance in the external globus pallidus
Erick Olivares1, Charles J Wilson1
1Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, Texas, United States.
Journal of Neurophysiology
|July 28, 2025
Summary
Sparse mutual inhibition in the external globus pallidus (GPe) creates network resonance. Transmission delays in local connections amplify collective neuronal responses at specific frequencies.
Area of Science:
- Neuroscience
- Computational Neuroscience
Background:
- The external globus pallidus (GPe) is a key basal ganglia structure involved in motor control and learning.
- GPe neurons exhibit spiking resonance, preferentially encoding input frequencies near their firing rate.
Purpose of the Study:
- To investigate the emergence of network resonance in the GPe.
- To understand how neuronal interactions and transmission delays shape collective GPe output.
Main Methods:
- Computer simulations of a 1,000-neuron GPe network.
- Modeling sparse mutual inhibition and axonal/synaptic delays.
Main Results:
- Sparse mutual inhibition among GPe neurons generates collective network resonance.
- Network resonance is dependent on transmission delays within the local GPe network.
- This resonance amplifies collective responses to specific input frequencies without altering individual neuron firing rates.
Conclusions:
- Network resonance in the GPe arises from neuronal coherence driven by transmission delays.
- This mechanism allows the GPe network to selectively amplify relevant frequency components of synaptic input.
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