Related Experiment Video

Updated: Sep 13, 2025

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

12.4K

Differences between COVID-19 and non-COVID-19 patients' bloodstream infections: a single-center retrospective study

Çağla Keskin Sarıtaş1, Halit Özsüt2, Aysun Benli2

  • 1Department of Infectious Diseases and Clinical Microbiology, Marmara University Training and Research Hospital, Istanbul, Turkey.

Journal of Infection in Developing Countries
|July 28, 2025
PubMed

Insights

COVID-19 patients with intensive care unit (ICU)-associated bloodstream infections (BSIs) showed higher rates of multidrug-resistant (MDR) bacteria, linked to prior antibiotic use. These patients experienced shorter survival times post-BSI compared to non-COVID-19 patients.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Intensive care unit (ICU)-acquired bloodstream infections (BSIs) pose a significant threat to patient outcomes.
  • Understanding the specific characteristics of BSIs in coronavirus disease 2019 (COVID-19) patients is crucial for effective management.

Purpose of the Study:

  • To compare epidemiological, clinical, microbiological, and outcome data of COVID-19 and non-COVID-19 patients with ICU-acquired BSIs.
  • To identify risk factors associated with mortality in BSI patients.

Main Methods:

  • A retrospective study of 234 patients with ICU-acquired BSIs between March 2020 and April 2022.
  • Patients were categorized into COVID-19 (n=127) and non-COVID-19 (n=107) groups.
  • Descriptive statistics and logistic regression analysis were employed to compare groups and identify mortality risk factors.

Main Results:

  • COVID-19 patients had a higher incidence of respiratory sources for BSIs (43.3% vs. 26%).
  • Acinetobacter baumannii and Gram-negative multidrug-resistant (MDR) bacteria were significantly more prevalent in COVID-19 patients (24.4% vs. 5.6% and 81.7% vs. 61.7%, respectively).
  • Longer prior antibiotic use in COVID-19 patients was associated with MDR Gram-negative bacterial BSIs, and COVID-19 patients had shorter survival times post-BSI.

Conclusions:

  • Multidrug-resistant microorganisms are prevalent in COVID-19 patients with ICU-acquired BSIs.
  • Prior antibiotic use in hospitals contributes to the development of MDR bacterial BSIs in COVID-19 patients.
  • COVID-19 is associated with poorer outcomes in patients with ICU-acquired BSIs.
Abstract

Keywords:
BSICOVID-19associatedfivenosocomial infectionsix

More Related Videos

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes05:58

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes

Published on: March 22, 2022

4.2K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.4K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Controls in Experiments01:13

Controls in Experiments

When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
11.2K
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
26
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.9K