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Facile Preparation of 4-Substituted Quinazoline Derivatives
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Exploring the Anticancer Properties of Quinoxaline-Based Molecules: A Systematic Review

Eman K A Abdelall1, Heba A H Elshemy1, Noha Ryad2

  • 1Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Chemistry & Biodiversity
|July 28, 2025
PubMed

Insights

Quinoxaline derivatives show promise as novel anticancer agents, offering potential treatments with fewer side effects than traditional chemotherapy. This review highlights their efficacy in combating cancer pathways.

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Oncology

Background:

  • Cancer remains a leading global cause of death, necessitating new therapeutic strategies.
  • Current chemotherapy drugs often lack specificity and cause significant adverse effects.
  • Quinoxaline derivatives are emerging as a promising class of compounds for cancer treatment.

Purpose of the Study:

  • To review and synthesize research on the anticancer efficacy of quinoxaline derivatives.
  • To summarize findings from studies published between 2015 and 2024.
  • To highlight the potential of quinoxaline derivatives in future cancer therapies.

Main Methods:

  • Comprehensive literature search of scientific databases.
  • Inclusion of studies focusing on quinoxaline derivatives' anticancer activity.
  • Analysis and summarization of reported efficacy and mechanisms of action.

Main Results:

  • Numerous quinoxaline derivatives demonstrate significant anticancer activity against various cancer types.
  • These compounds show potential in inhibiting key cancer-related pathways and enzymes.
  • The review covers a decade of research (2015-2024) showcasing consistent findings.

Conclusions:

  • Quinoxaline derivatives represent a promising scaffold for developing novel anticancer drugs.
  • Their targeted action may offer improved specificity and reduced side effects compared to conventional chemotherapy.
  • Further research and clinical trials are warranted to fully realize their therapeutic potential.
Keywords:
EGFRVEGFR‐2cytotoxicityquinoxalinetopoisomerases (Topo) and tubulin

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