Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.0K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

7.5K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Added value of point-of-care testing for Group A Streptococcus in community pharmacy sore throat pathways: analysis of the Wales Sore Throat Test and Treat service.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Outcomes of Isolated Femoral Head and Polyethylene Liner Exchange in Revision Total Hip Arthroplasty.

Hip & pelvis·2026
Same author

Outpatient Total Joint Arthroplasty: Future Directions.

The Journal of bone and joint surgery. American volume·2026
Same author

The Anterior Cruciate Ligament Injury Severity Scale (ACLISS) as a Predictor of Short-Term Reoperation and Functional Outcomes After ACL Reconstruction.

The American journal of sports medicine·2026
Same author

Mammographic surveillance in breast cancer patients aged 50 years or older: a synopsis of the Mammo-50 RCT.

Health technology assessment (Winchester, England)·2026
Same author

Real-World Safety and Effectiveness of 24-Hour Foslevodopa/Foscarbidopa in Parkinson's Disease: ROSSINI Study 6-Month Interim Results.

Neurology and therapy·2026

Related Experiment Video

Updated: Sep 13, 2025

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.2K

Current Concepts in Neurogenic Heterotopic Ossification.

Jonathan Liu1, Noah Gilreath2, Sydney Rozenfeld1

  • 1Brown University, Department of Orthopaedics, Providence, RI.

Rhode Island Medical Journal (2013)
|July 28, 2025
PubMed
Summary

Heterotopic ossification (HO) is abnormal bone growth, often after brain or spinal cord injuries. Understanding its causes and improving treatments like physical therapy are crucial for patient recovery.

Keywords:
Heterotopic ossificationbisphosphonatesindomethacinphysical therapyradiation therapyrehabilitationtraumatic brain injury

More Related Videos

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration
09:07

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration

Published on: January 26, 2024

2.6K
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.5K

Related Experiment Videos

Last Updated: Sep 13, 2025

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

10.2K
Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration
09:07

Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration

Published on: January 26, 2024

2.6K
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.5K

Area of Science:

  • Orthopedics
  • Neurology
  • Regenerative Medicine

Background:

  • Heterotopic ossification (HO) is abnormal bone formation in soft tissues, commonly affecting the hip and elbow.
  • Neurogenic heterotopic ossification (NHO) can arise after traumatic brain injury (TBI) or spinal cord injury, leading to significant functional impairment.
  • The exact pathophysiology of NHO involves complex interactions between trauma, central nervous system signaling, and local mediators.

Purpose of the Study:

  • To review the current understanding of heterotopic ossification, particularly neurogenic HO.
  • To discuss diagnostic methods and treatment strategies for HO.
  • To present a case study of NHO in a poly-traumatized patient.

Main Methods:

  • Literature review of HO pathophysiology, diagnosis, and treatment.
  • Analysis of diagnostic tools including laboratory tests, plain radiographs, and advanced imaging (bone scan, CT).
  • Case report of a patient with TBI and spinal injury who developed NHO post-acetabular fixation.

Main Results:

  • HO causes pain, stiffness, and contractures, limiting daily activities.
  • Diagnosis utilizes a combination of clinical, laboratory, and imaging findings.
  • Treatment options include anti-inflammatory drugs, bisphosphonates, radiation, surgery, and physical therapy, with variable outcomes.

Conclusions:

  • NHO is a debilitating complication of neurological injury requiring multidisciplinary management.
  • Early diagnosis and a combination of medical and rehabilitative interventions are essential.
  • Further research into NHO pathophysiology may lead to more effective preventative and therapeutic strategies.